EurekAlert!

Rapid and accurate diagnosis of urinary tract infections using targeted next-generation sequencing: A multicenter comparative study with metagenomic sequencing and traditional ...

Urinary tract infections (UTIs) rank among the most prevalent bacterial infections globally. Traditional urine culture methods have significant limitations in detection time and sensitivity, prompting ...
Medscape

Targeted Next-Generation Sequencing: The Clinician's Stethoscope for Genetic Disorders

Personalized Medicine. 2014;11(6):581-592. Both enrichment methods were able to efficiently enrich the overlapping target region. Estimated enrichment factors were in the mean 4400-fold (SD ± 1613) ...
Nature

Metagenomic Next-Generation Sequencing in Infectious Disease Diagnosis

Metagenomic next‐generation sequencing (mNGS) is revolutionising infectious disease diagnosis by enabling an unbiased interrogation of all genetic material within a clinical sample. This approach ...
MedPage Today

Next-Gen Sequencing in NSCLC: What Works and What Lies Ahead

The ongoing Italian clinical and research FPG500 program is designed to tailor matched targeted therapies (MTTs) based on "biomarkers predictive of response identified by comprehensive genome profiling ...
ascopubs.org

Real-World Clinical Utility of Tumor Next-Generation Sequencing in Adolescent and Young Adult Patients With Sarcoma

Pansarcoma Analysis of Cyclin-Dependent Kinase and Cyclin Outlier Gene Expression Highlights CDK7 as a Potential Therapeutic Target in Chordoma A retrospective cohort study was conducted at Chris ...
EurekAlert!

Pediatric investigation review highlights the future of newborn screening with next-generation sequencing

Routine newborn screening (NBS) has transformed early disease detection. However, traditional biochemical tests limit the range of conditions that can be identified at birth. Next-generation ...