结构和机制研究表明，mCpol是一种二腺苷酸环化酶，其产物c-di-AMP可以阻止效应蛋白2TMβ的毒性寡聚化。荧光显微镜对细胞的分析显示，缺乏mCpol可使2TMβ介导的细胞因内膜塌陷而死亡。这些发现揭示了一种针对病毒介导的免疫抑制的强大防御策略， ...

Last year, a ten-month-old baby in the US was the first person in the world to have their rare genetic disease effectively ...

Nobel Prize winner and CRISPR DNA-editing pioneer Jennifer A. Doudna, PhD, spoke Thursday at Fred Hutch Cancer Center in Seattle. Her lecture kicked off the President’s Seminar series, presented by ...

Banas is associate director of research at the Gene Editing Institute at ChristianaCare, where Kmiec is founder and executive director. The medical promise of CRISPR gene editing can be seen most ...

At the heart of this technology is the Cas9 protein, often likened to molecular scissors, capable of cutting strands of DNA at specific locations dictated by a single guide RNA. With this mechanism, ...

Breakthroughs, discoveries, and DIY tips sent six days a week. Terms of Service and Privacy Policy. Tardigrades are going under the knife. At least their genes are. A ...

Picture CRISPR-Cas9, a gene editing technology, as a GPS-guided scalpel: gRNA directs the Cas9 enzyme, a protein that cuts ...

SAN DIEGO--(BUSINESS WIRE)--VedaBio, a biotechnology company leading a paradigm shift in molecular detection, today announced the appointment of G. Brett Robb, Ph.D., as Senior Scientific Director and ...

Crispr instruments. Image by Tim Sandle (taken at the Design Museum, London). Crispr instruments. Image by Tim Sandle (taken at the Design Museum, London). Scientists are hailing a key gene, said to ...

A new CRISPR breakthrough shows scientists can turn genes back on without cutting DNA, by removing chemical tags that act like molecular anchors. The work confirms these tags actively silence genes, ...

Scientists have used CRISPR to give the goldenberry a modern makeover, shrinking the plant by about a third and making it easier to farm. Goldenberries are tasty and nutritious but notoriously unruly, ...

本研究结果证实，可通过MRI示踪的PIO@Lipo能有效实现POLD4基因沉默，进而增强肿瘤对RT的敏感性。 放射治疗是前列腺癌的基础治疗手段，但其疗效常受限于由 DNA 修复机制及其他生物学因素介导的放射抵抗。基因治疗虽为克服这种抵抗带来了希望，但筛选有效的 ...