本研究针对胶质母细胞瘤(GBM)如何维持R-loop稳态以平衡转录需求与基因组稳定性这一关键问题，揭示了THOC1通过与SIN3A组蛋白去乙酰化复合物相互作用，特异性调控端粒区R-loop水平的新机制。研究人员发现靶向THOC1可破坏端粒稳定性，显著抑制GBM进展，为这一难治 ...

近日，广州医科大学附属妇女儿童医疗中心优生围产研究所李卫、刘超团队联合中国科学院动物研究所高飞团队，华南理工大学张美佳团队在Science Bulletin发表了题为“Dynamic R-loops at centromeres ensure chromosome alignment during oocyte meiotic divisions in mice”的研究论文，揭示 ...

Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

Kyle Miller and his team discovered a potential new target for drug therapies: structures in our DNA called R-loops. A human cancer cell that overexpresses the enzyme APOBEC3B (left) has fewer R-loops ...

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...