DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

In a study that appears in the journal Cell, scientists from San Francisco-based Gladstone Institutes—including co-first author Megan Ostrowski (left) and senior author Vijay Ramani, PhD ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

You can always be judged by your scars. This is the idea that sums up what researchers at Spanish National Cancer Research Centre (CNIO) claim is one of the new breakthroughs in basic and biomedical ...

非洲猪瘟是由ASFV引起的猪烈性传染病，具有高致死率，自2018年传入我国以来，已造成巨大经济损失，严重威胁全球养猪业安全。由于ASFV基因组庞大复杂，编码蛋白众多，且缺乏有效抗病毒药物和商业化疫苗，其防控一直是全球兽医领域的重大难题。病毒DNA聚合酶作为基因组复制的核心“引擎”，是抗病毒药物开发的关键靶点，但ASFV的DNA聚合酶的复制机制此前尚未被完全解析。

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone ...

Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, ...

Franklin W. Stahl, an American molecular biologist whose landmark 1957-58 experiment with colleague Matthew Meselson revealed how DNA replicates, helping pave the way for a revolution in genetics ...

引言在细胞每一次分裂、每一次应对内外环境挑战的喧嚣中，我们的基因组(genome)正经历着持续的修订、涂抹甚至撕裂。在癌症和许多先天性疾病的基因组中，我们常常能看到一些令人匪夷所思的混乱景象：染色体片段的诡异扩增、莫名其妙的序列插入、以及如同地震后断 ...