New scientific methods could one day render animal studies—the standard in research laboratories for more than 100 ...

Cell signalling pathways are central to maintaining cellular homeostasis and regulating essential functions such as proliferation, apoptosis, and repair. In both cancer and neurodegenerative diseases, ...

Metabolism, far from being just a housekeeping function, underlies all changes in cell size and function ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer ...

The Immune Atlas identifies immune signatures in MM, enhancing outcome prediction and guiding personalized therapies by ...

Despite the immense amount of genetic material present in each cell, around 3 billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities. The ...

Researchers have for the first time identified degeneration-associated “molecular markers” —observable changes in cells and their gene-regulating networks—that are shared by several forms of dementia ...

Plants are increasingly encountering abiotic stressors, such as salinity, drought, heavy metals, microplastics, and various environmental contaminants, that ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...